Thyroid Peroxidase Antibody Testing (TPO)

It is possible for thyroid antibodies to be positive even in otherwise healthy people. Their presence tends to increase with age and is more common in women.

Mild to moderately elevated levels of TPO antibodies can be seen in a variety of diseases. Thyroid autoimmune diseases, however, usually lead to significantly increased concentrations. In general, higher TPO antibody levels are more often associated with autoimmune thyroid disease being present.

The presence of TPO antibodies may be linked to a higher risk of future thyroid disorders. Some individuals with normal thyroid function and positive TPO antibodies remain stable, while others may develop thyroid dysfunction over time. TPO antibodies are commonly considered alongside thyroid function tests such as TSH, FT4, and sometimes FT3 when results are reviewed over time.

Further testing and consultation with a medical professional is advised.