PLAC® Testing (Lp-PLA2)

Several studies have shown that an elevated PLAC® test (Lp-PLA2) is linked to a higher risk of cardiovascular diseases, including heart attack and stroke.

This cardiovascular risk is higher when other risk factors are also present, including high blood pressure, high cholesterol, or high hs-CRP levels. These results are often considered together to build a more complete risk profile. A complete cholesterol & hs-CRP test is available here.

Lifestyle changes are sometimes sufficient to lower Lp-PLA2 levels and reduce heart disease risk, although some individuals are managed more aggressively, including with medication, depending on the overall risk-factor pattern. This is commonly discussed with a GP and may be reviewed further as part of a clinical investigation.

Approaches associated with lower PLAC® levels often overlap with strategies used to lower cholesterol levels, including:

• A healthy diet low in saturated fats and high in whole-grain foods, vegetables, and fruits
• More exercise and lower body fat, which may also reduce blood pressure
• Stopping smoking and avoiding excessive alcohol consumption
• Gum disease; plaque on teeth can contribute to elevated Lp-PLA2 levels
• Some prescribed and over-the-counter medicines and supplements are associated with reduced Lp-PLA2 levels and are sometimes used as part of a structured treatment plan developed by a GP to address other risk factors

A high level suggests an increased risk of cardiovascular diseases such as heart attack, stroke, and hypertension. Lifestyle modification similar to that used for high cholesterol is often considered, and medication is sometimes used when lifestyle measures do not lower the level.