Interpretation of a high oestradiol result is often done with caution because levels naturally vary across the menstrual cycle and can also show day-to-day variation.
A range of metabolic conditions can be linked to increased oestradiol. Associations include impaired liver function, impaired kidney function, anaemia, and high blood pressure.
When FSH (follicle stimulating hormone) is also high (often taken as indicative of menopause), very high oestrogen levels can occur if a follicle becomes “super-stimulated”. This can happen when increased FSH reactivates an ovary.
Very high results can also occur with topical hormonal treatments (gels, creams, sprays) used within 72 hours before sample collection, as transfer to the blood sample can occur when using a lancet on a finger.
After a high oestradiol result, further testing is sometimes used to look at trends over time, and additional review may be used to clarify the cause. Interpretation of elevated or low oestrogen is complex and can depend on factors such as concomitant drug use, timing within the menstrual cycle, age, and sexual characteristics.