While the most common cause is iron deficiency anaemia, RBCs can be decreased by three mechanisms: loss, destruction, and impaired production. Sometimes, these mechanisms work together to lower RBC counts, which leads to anaemia.[11]
The following symptoms are commonly associated with low RBC counts:
- Pallor.
- Weakness or fatigue.
- Feeling cold in the hands and feet.
- Dizziness.
- Headaches.
- Shortness of breath.
- Irregular or fast heartbeats.
- Chest pain.
Usually, these symptoms will be mild or completely absent, especially if you have had anaemia for a very long time. The best way to clinically identify a low RBC count sometimes requires recognising its cause, which frequently displays more specific and clear signs.
Blood loss is a common way to lose RBCs. If the loss is significant or prolonged, it may lead to anaemia. Common causes include surgery, childbirth, injuries, cancer, heavy menstruations, bloody urine, bloody or black stools, and other problems.[11][12]
Abnormal RBC destruction can be caused by haemolytic diseases, jaundice, certain viral and bacterial infections, malignant hypertension, and vascular devices.[11][12]
RBC production is impaired by deficiency of iron, vitamin B12, and folate. It is also commonly seen in people with cancer, tuberculosis, and bone marrow disorders.[11][12]